Carcinogenesis In a very lifetime carcinogenicity review performed in B6C3F1 mice, methylphenidate prompted an increase in hepatocellular adenomas, and in males only, a rise in hepatoblastomas at a each day dose of roughly sixty mg/kg/day. This dose is around 2 times the MRHD of sixty mg/day presented to young children on mg/m2 basis.• Educate su